Philadelphia, Pennsylvania and Oxford, United Kingdom--(Newsfile Corp. - August 13, 2025) - Adaptimmune Therapeutics plc (NASDAQ: ADAP) today reported financial results and provided a business update for the second quarter ended June 30, 2025.
Adrian Rawcliffe, Adaptimmune's Chief Executive Officer: "The launch of TECELRA continued to accelerate through Q2 with an increase of over 150% in patients invoiced and in revenue. The full network of ATCs is close to completion with 30 now accepting referrals. Our manufacturing organization continues to deliver with a 100% commercial manufacturing success rate through to the end of Q2. The transaction with US WorldMeds will ensure that patient access to TECLRA continues and also places lete-cel in capable hands leading up to its planned launch in 2026. As we noted when we announced the transaction on July 28, this deal follows an extensive review of strategic alternatives and represents the best path forward for Adaptimmune, our patients and stakeholders. Since closing the transaction on July 31, we have repaid our debt facility with Hercules Capital and are restructuring to support the assets transferred to US WorldMeds, and to maximize value from our remaining assets including programs targeting PRAME and CD70."
Financial Results for the six months ended June 30, 2025
[1] Total liquidity is a non-GAAP financial measure, which is explained and reconciled to the most directly comparable financial measures prepared in accordance with GAAP below.
As a result of the transaction with US WorldMeds and repayment of all sums under the loan agreement with Hercules Capital Inc, we consider that the cash and cash equivalents of the Company will be sufficient to meet our planned operating requirements through the 12 months following the filing of our Quarterly Report for the second quarter of 2025.
About Adaptimmune
Adaptimmune is a fully integrated cell therapy company working to redefine how cancer is treated. With its unique engineered T cell receptor (TCR) platform, the Company is developing personalized medicines designed to target and destroy difficult-to-treat solid tumor cancers and to radically improve the patient's cancer treatment experience.
Forward-Looking Statements
This release contains "forward-looking statements" within the meaning of the safe harbor provisions of Section 27A of the Securities Act and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements address our expected future business, financial performance, financial condition, as well as the results of operations and often contain words such as "anticipate" "believe," "expect," "may," "plan," "potential," "will," and similar expressions. Such statements are based only upon current expectations of Adaptimmune. Reliance should not be placed on these forward-looking statements because they involve certain risks and uncertainties. Such risks and uncertainties could cause our actual results to differ materially from those indicated by such forward-looking statements, and include, without limitation: the success, cost and timing of our product development activities and clinical trials and our ability to successfully advance our TCR therapeutic candidates through the regulatory and commercialization processes. For a further description of the risks and uncertainties that could cause our actual results to differ materially from those expressed in these forward-looking statements, as well as risks relating to our business in general, we refer you to our Annual Report on Form 10-K filed with the Securities and Exchange Commission for the year ended December 31, 2024, our Quarterly Reports on Form 10-Q, Current Reports on Form 8-K, and other filings with the Securities and Exchange Commission. The forward-looking statements contained in this press release speak only as of the date the statements were made and we do not undertake any obligation to update such forward-looking statements to reflect subsequent events or circumstances.
Total Liquidity (a non-GAAP financial measure)
Total Liquidity (a non-GAAP financial measure) is the total of cash and cash equivalents and marketable securities (available-for-sale debt securities). Each of these components appears separately in the condensed consolidated balance sheet. The U.S. GAAP financial measure most directly comparable to Total Liquidity is cash and cash equivalents as reported in the condensed consolidated financial statements, which reconciles to Total Liquidity as follows (in thousands):
| June 30, | December 31, | ||||||||
| 2025 | 2024 | ||||||||
| Cash and cash equivalents | $ | 26,061 | $ | 91,139 | |||||
| Marketable securities - available-for-sale debt securities | — | 60,466 | |||||||
| Total Liquidity | $ | 26,061 | $ | 151,605 | |||||
The Company believes that the presentation of Total Liquidity provides useful information to investors because management reviews Total Liquidity as part of its assessment of overall solvency and liquidity, financial flexibility, capital position and leverage.
Condensed Consolidated Statement of Operations
(unaudited, in thousands, except per share data)
| Three months ended | Six months ended | ||||||||||||||||||
| June 30, | June 30, | ||||||||||||||||||
| 2025 | 2024 | 2025 | 2024 | ||||||||||||||||
| Revenue: | |||||||||||||||||||
| Product revenue, net | $ | 11,078 | $ | — | $ | 15,126 | $ | — | |||||||||||
| Development revenue | 2,599 | 128,231 | 5,836 | 133,909 | |||||||||||||||
| Total revenue | 13,677 | 128,231 | 20,962 | 133,909 | |||||||||||||||
| Operating expenses: | |||||||||||||||||||
| Cost of goods sold | (2,501) | — | (3,380) | — | |||||||||||||||
| Research and development | (22,979) | (40,448) | (51,836) | (75,655) | |||||||||||||||
| Selling, general and administrative | (18,485) | (19,083) | (41,767) | (38,815) | |||||||||||||||
| Total operating expenses | (43,965) | (59,531) | (96,983) | (114,470) | |||||||||||||||
| (Loss)/profit from operations | (30,288) | 68,700 | (76,021) | 19,439 | |||||||||||||||
| Interest income | 233 | 1,376 | 1,143 | 2,721 | |||||||||||||||
| Interest expense | (962) | (526) | (2,843) | (526) | |||||||||||||||
| Other income (expense), net | 1,289 | 497 | 984 | 436 | |||||||||||||||
| (Loss)/profit before income tax expense | (29,728) | 70,047 | (76,737) | 22,070 | |||||||||||||||
| Income tax expense | (612) | (526) | (1,187) | (1,052) | |||||||||||||||
| Net (loss)/profit attributable to ordinary shareholders | $ | (30,340) | $ | 69,521 | $ | (77,924) | $ | 21,018 | |||||||||||
| Net (loss)/profit per ordinary share | |||||||||||||||||||
| Basic | $ | (0.02) | $ | 0.05 | $ | (0.05) | $ | 0.01 | |||||||||||
| Diluted | $ | (0.02) | $ | 0.04 | $ | (0.05) | $ | 0.01 | |||||||||||
| Weighted average shares outstanding: | |||||||||||||||||||
| Basic | 1,584,522,868 | 1,533,531,837 | 1,563,458,270 | 1,492,386,749 | |||||||||||||||
| Diluted | 1,584,522,868 | 1,559,183,774 | 1,563,458,270 | 1,519,004,675 | |||||||||||||||
Condensed Consolidated Balance Sheets
(unaudited, in thousands, except share data)
| June 30, | December 31, | |||||||||
| 2025 | 2024 | |||||||||
| Assets | ||||||||||
| Current assets | ||||||||||
| Cash and cash equivalents | $ | 26,061 | $ | 91,139 | ||||||
| Marketable securities - available-for-sale debt securities (amortized cost of $0 and $60,451) net of allowance for expected credit losses of $0 and $0 | — | 60,466 | ||||||||
| Accounts receivable, net of allowance for expected credit losses of $0 and $0 | 9,313 | 1,454 | ||||||||
| Inventory, net | 11,411 | 7,320 | ||||||||
| Other current assets and prepaid expenses | 31,330 | 27,790 | ||||||||
| Total current assets | 78,115 | 188,169 | ||||||||
| Restricted cash | 1,717 | 2,067 | ||||||||
| Other non-current assets | 94 | 629 | ||||||||
| Operating lease right-of-use assets, net of accumulated amortization of $20,721 and $17,750 | 18,748 | 19,909 | ||||||||
| Property, plant and equipment, net of accumulated depreciation of $75,028 and $51,893 | 28,152 | 31,309 | ||||||||
| Intangible assets, net of accumulated amortization of $6,141 and $5,567 | 3,807 | 3,880 | ||||||||
| Total assets | $ | 130,633 | $ | 245,963 | ||||||
| Liabilities and stockholders' equity | ||||||||||
| Current liabilities | ||||||||||
| Accounts payable | $ | 9,418 | $ | 8,692 | ||||||
| Operating lease liabilities, current | 4,514 | 4,709 | ||||||||
| Accrued expenses and other current liabilities | 24,526 | 32,919 | ||||||||
| Restructuring provision | 2,355 | 5,911 | ||||||||
| Deferred revenue, current | 10,700 | 12,296 | ||||||||
| Total current liabilities | 51,513 | 64,527 | ||||||||
| Operating lease liabilities, non-current | 18,491 | 19,263 | ||||||||
| Deferred revenue, non-current | 101,419 | 95,815 | ||||||||
| Borrowings, non-current | 25,675 | 50,237 | ||||||||
| Other liabilities, non-current | 4,493 | 4,272 | ||||||||
| Total liabilities | 201,591 | 234,114 | ||||||||
| Stockholders' equity | ||||||||||
| Common stock - Ordinary shares par value £0.001, 2,108,130,546 authorized and 1,590,309,546 issued and outstanding (2024: 2,039,252,874 authorized and 1,535,653,620 issued and outstanding) | 2,156 | 2,085 | ||||||||
| Additional paid in capital | 1,109,409 | 1,105,653 | ||||||||
| Accumulated other comprehensive loss | (10,612) | (1,902) | ||||||||
| Accumulated deficit | (1,171,911) | (1,093,987) | ||||||||
| Total stockholders' equity | (70,958) | 11,849 | ||||||||
| Total liabilities and stockholders' equity | $ | 130,633 | $ | 245,963 | ||||||
Condensed Consolidated Cash Flow Statement
(unaudited, in thousands)
| Six months ended | ||||||||
| June 30, | ||||||||
| 2025 | 2024 | |||||||
| Cash flows from operating activities | ||||||||
| Net (loss)/profit | $ | (77,924) | $ | 21,018 | ||||
| Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||
| Depreciation | 4,620 | 5,457 | ||||||
| Amortization | 355 | 115 | ||||||
| Share-based compensation expense | 1,990 | 6,160 | ||||||
| Unrealized foreign exchange gains | (888) | (266) | ||||||
| Accretion of available-for-sale debt securities | (509) | (42) | ||||||
| Other | 56 | 2 | ||||||
| Changes in operating assets and liabilities: | ||||||||
| (Increase)/decrease in receivables and other operating assets | (9,158) | 20,788 | ||||||
| Increase in inventories | (4,041) | — | ||||||
| (Decrease)/increase in payables and other current liabilities | (11,407) | 1,012 | ||||||
| Decrease in noncurrent assets | 562 | — | ||||||
| Increase in borrowings and other non-current liabilities | 784 | 454 | ||||||
| Decrease in deferred revenue | (5,812) | (39,249) | ||||||
| Net cash (used in)/provided by operating activities | (101,372) | 15,449 | ||||||
| Cash flows from investing activities | ||||||||
| Acquisition of property, plant and equipment | (1,278) | (524) | ||||||
| Acquisition of intangible assets | — | (588) | ||||||
| Maturity, redemption or sale of marketable securities | 76,950 | — | ||||||
| Investment in marketable securities | (16,090) | — | ||||||
| Other | 62 | 11 | ||||||
| Net cash provided by/(used in) investing activities | 59,644 | (1,101) | ||||||
| Cash flows from financing activities | ||||||||
| Proceeds from issuance of borrowings, net of discount | — | 24,500 | ||||||
| Repayment of borrowings | (25,451) | — | ||||||
| Proceeds from issuance of common stock from offerings, net of commissions and issuance costs | 1,775 | 29,171 | ||||||
| Proceeds from exercise of stock options | 10 | 76 | ||||||
| Net cash (used in)/provided by financing activities | (23,666) | 53,747 | ||||||
| Effect of currency exchange rate changes on cash, cash equivalents and restricted cash | (34) | (436) | ||||||
| Net (decrease)/increase in cash, cash equivalents and restricted cash | (65,428) | 67,659 | ||||||
| Cash, cash equivalents and restricted cash at start of period | 93,206 | 147,017 | ||||||
| Cash, cash equivalents and restricted cash at end of period | $ | 27,778 | $ | 214,676 | ||||
Adaptimmune Contact
Investor Relations and Media Relations
Adrian Rawcliffe, Chief Executive Officer
This email address is being protected from spambots. You need JavaScript enabled to view it.
| Last Trade: | US$0.06 |
| Daily Change: | -0.0079 -11.47 |
| Daily Volume: | 39,295,213 |
| Market Cap: | US$16.170M |
December 19, 2024 | |
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