• Data to be presented for 167 enrolled participants of which 122 were evaluable for efficacy
• Company to host HNSCC KOL event to review and discuss data

NORWOOD, Mass., Oct. 14, 2025 (GLOBE NEWSWIRE) -- Corbus Pharmaceuticals Holdings Inc. (NASDAQ: CRBP), a clinical stage company focused on oncology and obesity, announced today the European Society for Medical Oncology (ESMO) Congress 2025 abstract for its Phase 1/2 clinical study has been released. Updated data will be presented as a poster during ESMO. The abstract describes safety data for 70 participants from an April 2025 data cut. The poster will present updated data from a September 1^st, 2025 data cut on 167 enrolled participants of which 122 participants were evaluable for efficacy with either head and neck squamous cell carcinoma (HNSCC)(n=41), cervical(n=37), metastatic urothelial tumors(n=23),or other tumor types enrolled during dose escalation(n=21).

The poster titled, “Phase 1/2 study of the next-generation Nectin-4-targeting antibody–drug conjugate CRB-701 (SYS6002) in patients with urothelial and non-urothelial solid tumours” by Perez et al, will be presented on Sunday, October 19 from 12:00-12:45 CEST (Poster # 967P).

Corbus will also host an in-person and virtual HNSCC KOL event to review and discuss the data. The event will be held at the Berlin Germany Marriott starting at 10AM CEST on Sunday October 19th. The event will feature insights from leading HNSCC experts:

• Ari Rosenberg, MD – University of Chicago
• Glenn Hanna, MD - Dana-Farber Cancer Institute
• Cesar Augusto Perez Batista, MD - Sarah Cannon Research Institute

A live question and answer session will follow the formal presentation. To register for the HNSCC KOL event, click here.

The ongoing CRB-701 Phase 1/2 clinical trial (NCT06265727) is being conducted in the U.S. and Europe is evaluating the safety, pharmacokinetics, and efficacy of CRB-701 in participants with advanced solid tumors known to be associated with high Nectin-4 expression. The study is enrolling primarily participants with either HNSCC or cervical tumors.

About CRB-701        

CRB-701 (SYS6002) is a next-generation antibody drug conjugate (ADC) targeting Nectin-4, that contains a site-specific, cleavable linker and a homogenous drug antibody ratio of 2, using monomethyl auristatin E (MMAE) as the payload. Nectin-4 is a clinically validated, tumor-associated antigen in urothelial cancer. The FDA has granted two Fast Track designations to CRB-701 in HNSCC and cervical cancer.                

About Corbus

Corbus Pharmaceuticals Holdings, Inc. is a clinical-stage company focused on oncology and obesity and is committed to helping people defeat serious illness by bringing innovative scientific approaches to well-understood biological pathways. Corbus’ pipeline includes CRB-701, a next-generation antibody drug conjugate that targets the expression of Nectin-4 on cancer cells to release a cytotoxic payload, CRB-601, an anti-integrin monoclonal antibody that blocks the activation of TGFβ expressed on cancer cells, and CRB-913, a highly peripherally restricted CB1 receptor inverse agonist for the treatment of obesity. Corbus is headquartered in Norwood, Massachusetts. For more information on Corbus, visit corbuspharma.com. Connect with us on X, LinkedIn and Facebook.

Forward-Looking Statements

This press release contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 and Private Securities Litigation Reform Act, as amended, including those relating to the Company’s trial results, product development, clinical and regulatory timelines, including timing for completion of trials and presentation of data, market opportunity, competitive position, possible or assumed future results of operations, business strategies, potential growth opportunities and other statements that are predictive in nature. These forward-looking statements are based on current expectations, estimates, forecasts and projections about the industry and markets in which we operate and management’s current beliefs and assumptions.

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INVESTOR CONTACTS:

Sean Moran
Chief Financial Officer
Corbus Pharmaceuticals
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Dan Ferry
Managing Director
LifeSci Advisors, LLC
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