BOULDER, Colo., Nov. 09, 2023 (GLOBE NEWSWIRE) -- Enliven Therapeutics, Inc. (Enliven) (Nasdaq: ELVN), a clinical-stage precision oncology company focused on the discovery and development of next-generation small molecule kinase inhibitors, today reported financial results for the third quarter ended September 30, 2023, and provided a business update.
“We made significant progress this past quarter,” said Sam Kintz, MBA, Enliven’s Co-founder and Chief Executive Officer. “Both of our parallel lead programs are advancing in their respective Phase 1 trials, and there continues to be strong patient demand for both trials. Our team is laser-focused on continuing to execute, and we look forward to sharing initial data for these programs next year.”
Recent Business Highlights and Upcoming Milestones
Research and Development Highlights
Third Quarter 2023 Financial Results
About Enliven Therapeutics
Enliven Therapeutics is a clinical-stage biopharmaceutical company focused on the discovery and development of small molecule inhibitors to help patients with cancer not only live longer, but better. Enliven aims to address existing and emerging unmet needs with a precision oncology approach that improves survival and enhances overall patient well-being. Enliven’s discovery process combines deep insights in clinically validated biological targets and differentiated chemistry to design potentially first-in-class or best-in-class therapies. Enliven is based in Boulder, Colorado.
Forward-Looking Statements
This press release contains forward-looking statements (including within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and Section 27A of the Securities Act of 1933, as amended )concerning Enliven and other matters. These statements may discuss goals, intentions and expectations as to future plans, trends, events, results of operations or financial condition, or otherwise, based on current beliefs of the management of Enliven, as well as assumptions made by, and information currently available to, management of Enliven. Forward-looking statements generally include statements that are predictive in nature and depend upon or refer to future events or conditions, and include words such as “may,” “will,” “should,” “would,” “expect,” “anticipate,” “plan,” “likely,” “believe,” “estimate,” “project,” “intend,” and other similar expressions or the negative or plural of these words, or other similar expressions that are predictions or indicate future events or prospects, although not all forward-looking statements contain these words. Statements that are not historical facts are forward-looking statements. Forward-looking statements in this press release include, but are not limited to, statements regarding the potential of, and plans and expectations regarding, Enliven’s programs, including ELVN-001, ELVN-002, Enliven’s third program and its early-stage discovery programs; Enliven’s pipeline of product candidates; the expected timing of initial results for ELVN-001 and ELVN-002; statements relating to Enliven’s expected cash runway; the expected timing of disclosure of more information on Enliven’s pipeline; and statements by Enliven’s Co-founder, President and Chief Executive Officer. Forward-looking statements are based on current beliefs and assumptions that are subject to risks and uncertainties and are not guarantees of future performance. Actual results could differ materially from those contained in any forward-looking statement as a result of various factors, including, without limitation: the limited operating history of Enliven; the significant net losses incurred since its inception; the ability to advance product candidates through preclinical and clinical development; the ability to obtain regulatory approval for, and ultimately commercialize, product candidates; the outcome of preclinical testing and early clinical trials for product candidates and the potential that the outcome of preclinical testing and early clinical trials may not be predictive of the success of later clinical trials; Enliven’s limited resources; the risk of adverse events, toxicities or other undesirable side effects; potential delays or difficulties in the enrollment or maintenance of patients in clinical trials; the decision to develop or seek strategic collaborations to develop Enliven’s current or future product candidates in combination with other therapies and the cost of combination therapies; Enliven’s limited experience as a company in designing and conducting clinical trials; the ability to attract, hire, and retain highly skilled executive officers and employees; the ability of Enliven to protect its intellectual property and proprietary technologies; the scope of any patent protection Enliven obtains or the loss of any of Enliven’s patent protection; developments relating to Enliven’s competitors and its industry, including competing product candidates and therapies; reliance on third parties, including contract manufacturing organizations, contract research organizations and strategic partners; general market or macroeconomic conditions; Enliven’s ability to obtain additional capital to fund Enliven’s general corporate activities and to fund Enliven’s research and development; and other risks and uncertainties, including those more fully described in Enliven’s filings with the Securities and Exchange Commission (SEC), including additional risks which may be found in the section entitled “Risk Factors” in Enliven’s Annual and Quarterly Reports on Form 10-K and 10-Q filed with the SEC and in Enliven’s future reports to be filed with the SEC. Except as required by applicable law, Enliven undertakes no obligation to revise or update any forward-looking statement, or to make any other forward-looking statements, whether as a result of new information, future events or otherwise.
This press release contains hyperlinks to information that is not deemed to be incorporated by reference into this press release.
Contact:
Enliven Investors & Media:
Argot Partners
This email address is being protected from spambots. You need JavaScript enabled to view it.
Enliven Therapeutics, Inc.
Selected Condensed Consolidated Financial Information
(in thousands, except per share data)
(unaudited)
| Statements of Operations | Three Months Ended September 30, | Nine Months Ended September 30, | |||||||||||||||
| 2023 | 2022 | 2023 | 2022 | ||||||||||||||
| Operating expenses: | |||||||||||||||||
| Research and development | $ | 19,606 | $ | 7,829 | $ | 46,669 | $ | 22,825 | |||||||||
| General and administrative | 4,642 | 3,105 | 14,131 | 5,803 | |||||||||||||
| Total operating expenses | 24,248 | 10,934 | 60,800 | 28,628 | |||||||||||||
| Loss from operations | (24,248 | ) | (10,934 | ) | (60,800 | ) | (28,628 | ) | |||||||||
| Other income (expense), net | 3,479 | 380 | 8,586 | 516 | |||||||||||||
| Net loss | $ | (20,769 | ) | $ | (10,554 | ) | $ | (52,214 | ) | $ | (28,112 | ) | |||||
| Net loss per share, basic and diluted | $ | (0.51 | ) | $ | (3.27 | ) | $ | (1.55 | ) | $ | (9.15 | ) | |||||
| Weighted-average shares outstanding, basic and diluted | 41,031 | 3,229 | 33,665 | 3,071 | |||||||||||||
| Balance Sheets | September 30, | December 31, | |||||||||||||||
| 2023 | 2022 | ||||||||||||||||
| Assets | |||||||||||||||||
| Current assets: | |||||||||||||||||
| Cash, cash equivalents and marketable securities | $ | 263,478 | $ | 75,536 | |||||||||||||
| Prepaid expenses and other current assets | 5,128 | 2,217 | |||||||||||||||
| Total current assets | 268,606 | 77,753 | |||||||||||||||
| Property and equipment, net | 806 | 890 | |||||||||||||||
| Operating lease right-of-use assets | 398 | 626 | |||||||||||||||
| Deferred offering costs | 563 | 3,975 | |||||||||||||||
| Restricted cash | 54 | 54 | |||||||||||||||
| Other long-term assets | 3,614 | — | |||||||||||||||
| Total assets | $ | 274,041 | $ | 83,298 | |||||||||||||
| Liabilities, Convertible Preferred Stock and Stockholders' Equity (Deficit) | |||||||||||||||||
| Current liabilities: | |||||||||||||||||
| Accounts payable | $ | 1,493 | $ | 3,438 | |||||||||||||
| Accrued expenses and other current liabilities | 10,586 | 6,277 | |||||||||||||||
| Total current liabilities | 12,079 | 9,715 | |||||||||||||||
| Long-term liabilities | 214 | 659 | |||||||||||||||
| Total liabilities | 12,293 | 10,374 | |||||||||||||||
| Convertible preferred stock | — | 149,749 | |||||||||||||||
| Stockholders' equity (deficit) | 261,748 | (76,825 | ) | ||||||||||||||
| Total liabilities, convertible preferred stock and stockholders' equity (deficit) | $ | 274,041 | $ | 83,298 | |||||||||||||
| Last Trade: | US$22.04 |
| Daily Change: | -0.01 -0.05 |
| Daily Volume: | 117,640 |
| Market Cap: | US$1.080B |
November 13, 2024 September 28, 2024 August 13, 2024 | |
Amneal Pharmaceuticals is a fully-integrated essential medicines company. We make healthy possible through the development, manufacturing, and distribution of generic and specialty pharmaceuticals. The Company has a diverse portfolio of over 250 products in its Generics segment and is expanding across...
CLICK TO LEARN MORE
Cue Biopharma is developing the first-ever class of therapeutics for the treatment of cancer that mimic the natural signals, or “Cues”, of the immune system. This novel class of injectable biologics selectively engages and modulates tumor-specific T cells directly within the patient’s body to transform...
CLICK TO LEARN MORE
