BRISBANE, Calif. / May 02, 2023 / Business Wire / Sangamo Therapeutics, Inc. (Nasdaq: SGMO), a genomic medicine company, today announced that the American Society of Gene & Cell Therapy (ASGCT) has accepted 14 Sangamo abstracts for presentation at the 26th ASGCT Annual Meeting being held May 16-20, 2023, in-person in Los Angeles, CA and in a virtual format. Presentations will focus on the progression of Sangamo’s pre-clinical programs, including data from the prioritized neurology programs Nav1.7 and Prion, innovations in the epigenetic regulation platform and advances in AAV capsid engineering for delivery.
“The data to be presented at ASGCT reflect important advances in areas core to our strategy, including epigenetic regulation for neurological disorders and engineered AAV capsids to potentially address the issues of delivery,” said Jason Fontenot, Ph.D., Chief Scientific Officer at Sangamo. “We are excited to share such a depth of pre-clinical data and look forward to presenting the innovation that continues to emerge from our research efforts, to potentially deliver transformative medicines to patients in need.”
Data to be presented at the ASGCT Annual Meeting include an oral presentation from Sangamo’s flagship neurology epigenetic regulation program Nav1.7 to treat chronic neuropathic pain. This presentation will showcase how Sangamo is using an optimized zinc finger epigenetic repressor to specifically target and seek to reduce Nav1.7 expression in dorsal root ganglions to inhibit pain sensation in diseases of chronic neuropathic pain. Beginning with Nav1.7-associated small fiber neuralgia, with an estimated prevalence of at least 43,000 patients in the US, future success in this indication could subsequently enable the broadened use of this therapy to other neuropathic pain indications, regardless of the cause of the pain.
Additional presentations at the ASGCT Annual Meeting will showcase how Sangamo is advancing its proprietary zinc finger platform development efforts, including the use of zinc finger transcriptional regulators designed to reduce the expression of the Prion protein for the treatment of Creutzfeldt-Jakob disease. Sangamo will also present data from its proprietary AAV capsid discovery platform SIFTER™, which enables the engineering of AAV capsids with the potential for highly improved central nervous system transduction efficiency, along with broader presentations showcasing Sangamo’s latest genomic engineering platform evolution.
ASGCT Annual Meeting Presentations and Invited Sessions
Epigenetic Regulation for the Central Nervous System
Viral Engineering for the Central Nervous System
Genomic Engineering Platform Evolution
Assays to Support Clinical Programs
All abstracts for the ASGCT Annual Meeting are available on ASGCT’s website.
About Sangamo Therapeutics
Sangamo Therapeutics is a clinical-stage biopharmaceutical company with a robust genomic medicines pipeline. Using ground-breaking science, including our proprietary zinc finger genome engineering technology and manufacturing expertise, Sangamo aims to create new genomic medicines for patients suffering from diseases for which existing treatment options are inadequate or currently don’t exist. To learn more, visit www.sangamo.com and connect with us on LinkedIn and Twitter.
Sangamo Forward-Looking Statements
This press release contains forward-looking statements based on Sangamo's current expectations. These forward-looking statements include, without limitation, statements relating to Sangamo’s technologies, the presentation of data from various therapeutic and research programs and the potential of these programs to demonstrate therapeutic benefit and transform the lives of patients. These statements are not guarantees of future performance and are subject to certain risks and uncertainties that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, the research development process, including the results of clinical trials; the regulatory approval process for product candidates; and the potential for technological developments that obviate technologies used by Sangamo. Actual results may differ from those projected in forward-looking statements due to risks and uncertainties that exist in Sangamo's operations and business. These risks and uncertainties are described more fully in our Securities and Exchange Commission filings and reports, including in our Annual Report on Form 10-K for the year ended December 31, 2022. Forward-looking statements contained in this announcement are made as of this date, and Sangamo undertakes no duty to update such information except as required under applicable law.
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